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Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer
Author(s) -
Wang Xiaodan,
Zhong Weiliang,
Bu Jingya,
Li Yuzhong,
Li Ruihua,
Nie Rong,
Xiao Chenyang,
Ma Keli,
Huang Xiaohua,
Li Ying
Publication year - 2019
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.22960
Subject(s) - tetraspanin , biology , breast cancer , microvesicles , biomarker , transmembrane protein , cancer research , cancer , exosome , metastasis , microrna , gene , genetics , receptor , cell
CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via tetra‐transmembrane protein enriched microdomains (TEMs) in exosomes. The present study aimed to explore the potential of the exosome protein CD82 in diagnosing breast cancers of all stages and various histological subtypes in patients. The results strongly suggest that CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. There was a significant negative correlation between CD82 expression in tissues and CD82 content in exosomes, which indicated that CD82 expression was redistributed from tissues to the blood with the development and metastasis of breast cancer.