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Circulating insulin‐like growth factor‐related biomarkers: Correlates and responses to calcium supplementation in colorectal adenoma patients
Author(s) -
Um Caroline Y.,
Fedirko Veronika,
Flanders W. Dana,
Höflich Christine,
Wirthgen Elisa,
Bostick Roberd M.
Publication year - 2017
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.22669
Subject(s) - medicine , endocrinology , colorectal adenoma , biology , adenoma , colorectal cancer , calcium , insulin like growth factor , igfbp3 , insulin like growth factor binding protein , growth factor , receptor , cancer
Circulating insulin‐like growth factor 1 (IGF‐1) may be directly associated with colorectal cancer risk, and IGF binding protein 3 (IGFBP‐3) is one of the most abundantly expressed binding proteins in various cancers. Calcium intakes, primarily from food, have been directly associated with circulating IGF‐1, but whether supplemental calcium affects IGF‐1 and IGFBP‐3 is unknown. We tested the effects of 1.0 and 2.0 g of supplemental elemental calcium daily on circulating IGF‐1 and IGFBP‐3 concentrations in colorectal adenoma patients in a randomized, double‐blinded, placebo‐controlled clinical trial ( n = 193). IGF‐1 and IGFBP‐3 were quantified using enzyme‐linked immunoassay and quantitative Western ligand blot, respectively. We also assessed cross‐sectional associations of these biomarkers with participants’ baseline characteristics. We found no appreciable effect of calcium relative to placebo on circulating IGF‐1, IGFBP‐3, or the IGF‐1:IGFBP‐3 molar ratio. Mean IGF‐1 concentrations were 11.1% higher in those with greater milk intakes ( P = 0.05). Mean IGF‐1 and IGFBP‐3 concentrations were, respectively, 18.0% ( P = 0.003) and 16.5% ( P = 0.01) higher in men and were monotonically lower with increasing age (both P = 0.01). IGFBP‐3 was 17.7% higher among those with higher relative to no alcohol consumption ( P = 0.04). While these results support previous findings that IGF‐1 concentrations are higher with greater milk intakes, and IGF‐1 and IGFBP‐3 concentrations differ according to sex and age, they provide no evidence to suggest that supplemental calcium appreciably affects circulating IGF‐1, IGFBP‐3, or the IGF‐1:IGFBP‐3 molar ratio in sporadic colorectal adenoma patients.