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PTENp1, a natural sponge of miR‐21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma
Author(s) -
Gao Ling,
Ren Wenhao,
Zhang Linmei,
Li Shaoming,
Kong Xinjuan,
Zhang Hao,
Dong Jianwei,
Cai Guangfeng,
Jin Changxiong,
Zheng Danqing,
Zhi Keqian
Publication year - 2017
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.22594
Subject(s) - pten , biology , competing endogenous rna , cancer research , rna , gene , long non coding rna , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , genetics
PTENp1, non‐coding RNA (ncRNA) pseudogene, is involved in oral squamous cell carcinoma (OSCC). The precise effects mediated by PTENp1 transcripts within intricate regulatory networks involving molecular interactions with ancestral gene PTEN and tumorigenicity in OSCC remain unclear. Here, we found that PTENp1 was aberrantly expressed in OSCC. There was a positive correlation between the expression levels of PTENp1 and PTEN. Further, we showed that PTENp1 acted as a competing endogenous RNA that protects PTEN transcripts from being inhibited by miR‐21, and consequently inhibited proliferation and colony formation and triggered S‐G2/M cell cycle arrest through the AKT pathway. Also, the homogeneous relationship between expression of PTENp1 and PTEN was confirmed in OSCC tumor xenografts. Finally, low expression of PTENp1 and PTEN was negatively associated with histological differentiation and OSCC prognosis. The present work provided the first evidence for the extraordinary crosstalk among PTENp1, PTEN, and miR‐21, and rendered a new light on the treatment of OSCC. © 2016 Wiley Periodicals, Inc.