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Decrease of 5‐hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid
Author(s) -
Lian Christine Guo,
Xu Shuyun,
Guo Weimin,
Yan Jian,
Frank Maximilian Y.M.,
Liu Robert,
Liu Cynthia,
Chen Ying,
Murphy George F.,
Chen Tao
Publication year - 2015
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.22201
Subject(s) - carcinogen , biology , 5 hydroxymethylcytosine , carcinogenesis , aristolochic acid , epigenetics , genetics , cancer research , toxicology , gene , gene expression , dna methylation
The level of 5‐hydroxymethylcytosine (5‐hmC) converted by ten‐eleven translocation (TET) family is decreased in cancers. However, whether 5‐hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5‐hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5‐hmC and TET2 expression decreased in the liver of the carcinogens‐treated rats. Loss of 5‐hmC correlates well with documented induction of genetic mutations by the carcinogens, suggesting that TET2‐mediated 5‐hydroxymethylation plays an epigenetic role in early state of carcinogenesis. © 2014 Wiley Periodicals, Inc.