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Potentially functional polymorphisms in aminoacyl‐tRNA synthetases genes are associated with breast cancer risk in a Chinese population
Author(s) -
He Yisha,
Gong Jianhang,
Wang Yanru,
Qin Zhenzhen,
Jiang Yue,
Ma Hongxia,
Jin Guangfu,
Chen Jiaping,
Hu Zhibin,
Guan Xiaoxiang,
Shen Hongbing
Publication year - 2015
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.22128
Subject(s) - biology , breast cancer , odds ratio , allele , single nucleotide polymorphism , oncology , case control study , cancer , confidence interval , genetics , medicine , carcinogenesis , genotype , gene
Aminoacyl‐tRNA synthetases (ARSs) are responsible for cellular protein synthesis and cell viability involving in various process of tumorigenesis. We hypothesized that genetic variants in core ARSs genes may play an important role in the development of breast cancer. Thus, we conducted a case–control study including 1064 breast cancer cases and 1073 cancer‐free controls to evaluate the associations of 28 potentially functional polymorphisms in 12 core ARSs genes ( AARS , CARS , EPRS , HARS , KARS , LARS , MARS , QARS , RARS , VARS , WARS , and YARS ) with breast cancer risk. We found significant associations with the risk of breast cancer for rs34087264 in AARS [odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.01–1.31], rs801186 in HARS (OR = 1.29, 95% CI = 1.08–1.54), rs193466 in RARS (OR = 1.17, 95% CI = 1.02–1.35), and rs2273802 in WARS (OR = 1.14, 95% CI = 1.01–1.30). We further observed significant interactions between rs2273802 and age at the first live birth ( P = 0.041), and between rs801186 and age on breast cancer risk ( P = 0.018). Combined analysis of these four SNPs showed a significant allele‐dosage association between the number of risk alleles and breast cancer risk ( P trend = 2.00 × 10 −4 ). Compared with individuals with “0–2” risk alleles, those carrying “3,” “4,” or “5 or more” risk alleles had a 1.32 (95% CI = 1.07–1.64), 1.48 (95% CI = 1.45–1.91), or 1.60 folds (95% CI = 1.06–2.41) risk of breast cancer, respectively. These findings indicate that genetic variants in core ARSs genes may modify the individual susceptibility to breast cancer in Chinese population. © 2014 Wiley Periodicals, Inc.