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Association of the miR‐146 aC>G, 149 C>T, 196a2 C>T, and 499 A>G polymorphisms with colorectal cancer in the Korean population
Author(s) -
Min Kyung Tae,
Kim Jong Woo,
Jeon Young Joo,
Jang Moon Ju,
Chong So Young,
Oh Doyeun,
Kim Nam Keun
Publication year - 2012
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.21849
Subject(s) - colorectal cancer , genotype , microrna , biology , single nucleotide polymorphism , medicine , population , gene , oncology , cancer , genetics , environmental health
MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR‐146a C>G (rs2910164), 149 C>T (rs2292832), 196a2 C>T (rs11614913), and 499 A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the miR‐196a2 CC genotype compared with the TT/CT genotype (AOR = 1.50; 95% CI = 1.11–2.04; P = 0.01; FDR‐P = 0.04). In the stratified analyses, we observed both weak and strong association data. We found stronger associations of the miR‐196a2 variants in the non‐diabetic and rectal cancer groups than other stratified groups. Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. © 2011 Wiley Periodicals, Inc.