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Genetic polymorphism in the 3′‐untranslated region of the E‐cadherin gene is associated with risk of different cancers
Author(s) -
Li Yan,
Tang Yuanjia,
Zhou Rongmiao,
Sun Donglan,
Duan Yanan,
Wang Na,
Chen Zhifeng,
Shen Nan
Publication year - 2011
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20765
Subject(s) - biology , genetics , gene , three prime untranslated region , untranslated region , polymorphism (computer science) , allele , rna
The genetic polymorphisms in E‐cadherin gene ( CDH1 ) may affect invasive/metastatic disease development by altering gene transcriptional activity. In this paper, we investigated the effect of 3′‐UTR +54C/T polymorphism (rs1801026) in CDH1 gene on the risk and progression of several common cancers. Multiple completely independent case‐control analyses of 1081 cancer patients with esophageal squamous cell carcinoma (ESCC), gastric cardiac adenocarcinoma (GCA), non‐small‐cell lung cancer (NSCLC), and cervical cancer and 1131 control subjects in northern Chinese populations. The results showed that the carriers with T allele were significantly decreased the risk of developing GCA, NSCLC, and cervical cancer, with an adjusted odds ratio of 0.67 (95% CI = 0.48–0.91), 0.68 (95% CI = 0.49–0.92), and 0.66 (95% CI = 0.48–0.92), respectively. There were no association between the frequency of genotype and the clinicopathological features of ESCC, GCA, and NSCLC, but the frequency of T allele was significantly lower in patients of stage III cervical cancer ( P = 0.026). These results suggested that the 3′‐UTR +54C/T polymorphism in CDH1 may be a marker for genetic susceptibility of cancer. © 2011 Wiley Periodicals, Inc.