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Pigment epithelium‐derived factor as an impending therapeutic agent against vascular epithelial growth factor‐driven tumor‐angiogenesis
Author(s) -
Manalo Katrina B.,
Choong Peter F.M.,
Dass Crispin R.
Publication year - 2011
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20711
Subject(s) - angiogenesis , biology , pedf , cancer research , vascular endothelial growth factor , metastasis , cancer , growth factor , vascular endothelial growth factor a , immunology , vegf receptors , receptor , biochemistry , genetics
In spite of the recent epidemiological study indicating a positive decrease in cancer trends, cancer remains to be one of the major causes of deaths and there is an anticipated increase in the number of new cancer cases to be recorded in the following years to come. It is important for researchers to improve the current therapeutic agents involved against cancer, particularly targeting to inhibit tumor cell growth, survival, and metastasis. Many researchers investigate the crucial role of a proangiogenic factor, vascular endothelial growth factor (VEGF) in the process of tumor angiogenesis, where the formation of new blood vessels carrying essential nutrients to the tumor cell becomes a critical factor for tumor growth. Since the establishment of VEGF's integral role in mediating tumor angiogenesis and tumor cell survival, current efforts are dedicated to developing therapeutic agents against VEGF and one of the emerging candidate under this category is pigment epithelium‐derived factor (PEDF). © 2010 Wiley‐Liss, Inc.