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The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population
Author(s) -
Wu Yinyin,
Jin Mingjuan,
Liu Bing,
Liang Xia,
Yu Yunxian,
Li Qilong,
Ma Xinyuan,
Yao Kaiyan,
Chen Kun
Publication year - 2011
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20704
Subject(s) - xeroderma pigmentosum , odds ratio , genotype , biology , colorectal cancer , haplotype , allele , medicine , confidence interval , case control study , population , oncology , genetics , gastroenterology , cancer , gene , dna repair , environmental health
Abstract The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix‐distorting DNA lesions. Several polymorphisms of XPC gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of XPC Lys939Gln (A/C), Ala499Val (C/T), and PAT (−/+) polymorphisms with CRC risk in a population‐based case–control study which included 421 CRC patients and 845 controls. For Lys939Gln, the CC genotype was associated with a significantly increased risk of CRC (odds ratio (OR) = 1.5; 95% confidence interval (CI) = 1.0−2.2) compared with the AA genotype. The subjects with PAT +/+ genotype had a significantly increased risk of CRC (OR = 1.5; 95% CI = 1.0−2.3), compared with those with PAT−/− genotype. Though no significant association between Ala499Val and CRC risk was observed, we found that individuals carrying the CT + TT genotypes showed a significantly decreased risk of rectal cancer (OR = 0.7; 95% CI = 0.5−1.0). Additionally, the haplotype C + C was associated with a significantly increased CRC risk (OR = 1.3; 95% CI = 1.0−1.6), compared with the most common haplotype A‐T. Further, individuals with four or more risk alleles exhibited a significantly increased risk of CRC (OR = 1.4; 95% CI = 1.0−2.0), with a significant gene‐dosage effect ( P for trend = 0.038). Besides, never tea drinking was associated with a significantly increased risk of CRC (OR = 2.3; 95% CI = 1.7−3.3). Our results suggest that the XPC polymorphisms may modulate CRC susceptibility independently or jointly, and tea drinking has a protective effect on CRC. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.