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The skinny on slug
Author(s) -
Shirley Stephanie H.,
Hudson Laurie G.,
He Jing,
Kusewitt Donna F.
Publication year - 2010
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20674
Subject(s) - slug , biology , transcription factor , epidermis (zoology) , keratinocyte , microbiology and biotechnology , zinc finger transcription factor , zinc finger , immunology , anatomy , cancer research , in vitro , genetics , gene
The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound healing, skin cancer, and sunburn. Slug is expressed in basal keratinocytes and hair follicles where it is important in maintaining epidermal homeostasis. Slug also helps coordinate the skin response to exogenous stimuli. Slug is rapidly induced by a variety of growth factors and injurious agents and Slug controls, directly or indirectly, a variety of keratinocyte responses, including changes in differentiation, adhesion, motility, and production of inflammatory mediators. Slug thus modulates the interactions of the keratinocyte with its environment and with surrounding cells. The function of Slug in the epidermis appears to be distinct from that of the closely related Snail transcription factor. © 2010 Wiley‐Liss, Inc.