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Models for chromosomal replication‐independent non‐B DNA structure‐induced genetic instability
Author(s) -
Wang Guliang,
Vasquez Karen M.
Publication year - 2009
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20508
Subject(s) - biology , dna replication , genome instability , genetics , dna , mutagenesis , dna re replication , control of chromosome duplication , gene , mutation , dna damage
Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B‐DNA form: many of these non‐B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences has been considered a major cause of non‐B form DNA structure‐induced genetic instability, it is also observed in non‐proliferative tissues. In this review, we discuss putative mechanisms responsible for the mutagenesis induced by non‐B DNA structures in the absence of chromosomal DNA replication. © 2009 Wiley‐Liss, Inc.