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Association between polymorphisms in the GSTA4 gene and risk of lung cancer: A case–control study in a Southeastern Chinese population
Author(s) -
Qian Ji,
Jing Jianying,
Jin Guangfu,
Wang Haifeng,
Wang Yi,
Liu Hongliang,
Wang Haijian,
Li Rui,
Fan Weiwei,
An Yu,
Sun Weiwei,
Wang Yi,
Ma Hongxia,
Miao Ruifeng,
Hu Zhibin,
Jin Li,
Wei Qingyi,
Shen Hongbing,
Huang Wei,
Lu Daru
Publication year - 2009
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20478
Subject(s) - lung cancer , genotype , biology , lung cancer susceptibility , single nucleotide polymorphism , cancer , medicine , allele , population , case control study , oncology , genetics , gene , environmental health
GST Alpha 4 (GSTA4) has an important role in the protection against oxidative stress induced by carcinogens such as tobacco smoke. However, few studies investigated the association between GSTA4 polymorphisms and lung cancer risk. We genotyped three selected GSTA4 SNPs (rs182623 − 1718:T > A, rs3798804 + 5034:G > A and rs316141 + 13984:C > T) in a case–control study of 500 lung cancer patients and 517 cancer‐free controls and evaluated the association between these SNPs and risk of lung cancer in this Han Chinese population. We found that there was a significant difference in genotype and allele frequency distributions of GSTA4 −1718 between the cases and the controls ( P = 0.006 and P = 0.003, respectively). Compared with the GSTA4 −1718TT genotype, individuals with the TA + AA genotypes had a significantly decreased risk of lung cancer (adjusted OR, 0.63; 95% CI, 0.47–0.84; P = 0.006). Although there were no such statistical differences between the cases and controls at the loci +5034 and +13984, nor for histological types, individuals carrying the genotypes of −1718TA, +5034GG and +13984CT had a significantly decreased lung cancer risk (OR, 0.37; 95% CI, 0.23–0.61; P < 0.0001), especially for those smokers who smoked ≤25 pack‐years ( P < 0.1). These results need to be confirmed in larger studies with different ethnic groups. © 2008 Wiley‐Liss, Inc.