Premium
Potentially functional polymorphisms of the vascular endothelial growth factor gene and risk of gastric cancer
Author(s) -
Ke Qiao,
Liang Jie,
Wang LiNa,
Hu ZhiBin,
Jin GuangFu,
Zhou Yan,
Wang JianMing,
Tan YongFei,
Hua ZhaoLai,
Xu YaoChu,
Shen Jing,
Shen HongBing
Publication year - 2008
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20435
Subject(s) - biology , single nucleotide polymorphism , genotype , haplotype , vascular endothelial growth factor , angiogenesis , logistic regression , gene , medicine , population , cancer , vegf receptors , oncology , case control study , genetics , bioinformatics , endocrinology , cancer research , environmental health
Vascular endothelial growth factor (VEGF), the key mediator of angiogenesis, plays an important role in the development of different kind of tumors, including gastric cancer (GC). The aim of this study is to test the hypothesis that genetic variants of VEGF are associated with risk of GC. We genotyped four potentially functional polymorphisms (−2578C > A, −1498T > C, −634G > C, and +936C > T) of the VEGF gene in a population‐based case–control study of 540 GC cases and 561 frequency‐matched cancer‐free controls in a high risk Chinese population. We found that none of the four polymorphisms or their haplotypes achieved significant difference in their distributions between GC cases and controls. Multiple logistic regression analyses revealed that GC risk was not significantly associated with the variant genotypes of the four VEGF polymorphisms as compared with their wild‐type genotypes. In conclusion, our data did not support a significant association between VEGF SNPs and the risk of GC. © 2008 Wiley‐Liss, Inc.