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A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
Author(s) -
Kangsamaksin Thaned,
Park Heui Joon,
Trempus Carol S.,
Morris Rebecca J.
Publication year - 2007
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20355
Subject(s) - biology , stem cell , hair follicle , cancer stem cell , perspective (graphical) , keratinocyte , microbiology and biotechnology , cancer research , immunology , cell culture , genetics , artificial intelligence , computer science
Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells. © 2007 Wiley‐Liss, Inc.