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Targeting Bcl‐X L for prevention and therapy of skin cancer
Author(s) -
Zhang Jack,
Bowden G. Tim
Publication year - 2007
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20330
Subject(s) - biology , cancer therapy , cancer , cancer research , computational biology , genetics
Apoptosis plays an important role in skin carcinogenesis. Bcl‐X L , an antiapoptotic Bcl‐2 family member, is a key regulator in the process. Aberrant expression of Bcl‐X L allows cells carrying mutations to survive and propagate. Overexpression of Bcl‐X L is correlated with tumor malignancy and invasion. Importantly, deregulation of Bcl‐X L confers drug resistance to chemotherapy. Therefore, targeting Bcl‐X L in combination with conventional chemotherapy is a promising way to pursue cancer chemotherapy. Several compounds targeting Bcl‐X L expression or function have shown their potential in chemoprevention and of chemotherapy of cancer. © 2007 Wiley‐Liss, Inc.