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Modeling normal and pathological processes through skin tissue engineering
Author(s) -
Garcia Marta,
Escamez Maria Jose,
Carretero Marta,
Mirones Isabel,
MartinezSantamaria Lucia,
Navarro Manuel,
Jorcano Jose L.,
Meana Alvaro,
Del Rio Marcela,
Larcher Fernando
Publication year - 2007
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20327
Subject(s) - regenerative medicine , human skin , biology , context (archaeology) , skin cancer , wound healing , humanized mouse , tissue engineering , genetic enhancement , pathology , cancer , immunology , stem cell , medicine , gene , immune system , microbiology and biotechnology , genetics , paleontology
Skin tissue engineering emerged as an experimental regenerative therapy motivated primarily by the critical need for early permanent coverage of extensive burn injuries in patients with insufficient sources of autologous skin for grafting. With time, the approach evolved toward a wider range of applications including disease modeling. We have established a skin‐humanized mouse model system consisting in bioengineered human‐skin‐engrafted immunodeficient mice. This new model allows to performing regenerative medicine, gene therapy, genomics, and pathology studies in a human context on homogeneous samples. Starting from skin cells (keratinocytes and fibroblasts) isolated from normal donor skin or patient's biopsies, we have been able to deconstruct‐reconstruct several inherited skin disorders including genodermatoses and cancer‐prone diseases in a large number of skin humanized mice. In addition, the model allows conducting studies in normal human skin to gain further insight into physiological processes such as wound healing or UV‐responses. © 2007 Wiley‐Liss, Inc.