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Association between Aurora‐A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population
Author(s) -
Chen Jinyun,
Sen Subrata,
Amos Christopher I.,
Wei Chongjuan,
Jones J. Shawn,
Lynch Patrick,
Frazier Marsha L.
Publication year - 2007
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20283
Subject(s) - biology , haplotype , colorectal cancer , single nucleotide polymorphism , genetics , allele , genotyping , cancer research , genotype , population , gene , cancer , medicine , environmental health
Abstract Aurora‐A kinase is considered a potential cancer susceptibility gene that encodes a centrosome‐associated, cell cycle‐regulated serine/threonine kinase. We studied two single nucleotide polymorphisms (SNP) in the coding region of Aurora‐A, 91T‐to‐A (F31I) and 169G‐to‐A (V57I). We studied the influence of these two polymorphisms on age of onset of hereditary nonpolyposis colorectal cancer (HNPCC). Genotyping of the Aurora‐A polymorphisms was carried out on 125 Caucasian with mismatch repair (MMR) gene mutations with real‐time pyrophosphate DNA sequencing. For the 91T‐to‐A polymorphism, we found that patients with HNPCC who were homozygous for the wild‐type allele developed colorectal cancer (CRC) 7 years earlier than patients who were homozygous or heterozygous for the mutant allele. The169G‐to‐A polymorphism did not have a significant influence on risk for HNPCC. However, when we did haplotype analysis for these two polymorphisms, the 91A‐169G haplotype was associated with protection from HNPCC at an earlier age. © 2006 Wiley‐Liss, Inc.