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No association of primary adenocarcinomas of the small bowel with Epstein‐Barr virus infection
Author(s) -
von Rahden Burkhard H.A.,
Langner Cord,
Brücher Björn L.D.M.,
Stein Hubert J.,
Sarbia Mario
Publication year - 2006
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20163
Subject(s) - biology , etiology , epstein–barr virus , small rna , virus , epstein–barr virus infection , gastroenterology , medicine , rna , cancer research , pathology , virology , gene , genetics
Epstein‐Barr Virus (EBV) infection is considered to play an etiologic role in human malignancies, including a subset of gastric and cardiac cancers. Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects. We have investigated the prevalence of EBER expression (EBV‐encoded small RNAs) in a series of small bowel adenocarcinomas (n = 56) utilizing RNA in situ hybridization (EBER‐RISH). The patients had undergone primary surgical resection at either the Technical University of Munich or at the University of Graz. A surgical series of 82 primary resected gastric (n = 36) or cardiac (n = 46) adenocarcinomas (TU Munich) was used as control group. None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers. These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas. © 2006 Wiley‐Liss, Inc.