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Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma
Author(s) -
Hashimoto Tomoko,
Uchida Kenichiro,
Okayama Naoko,
Imate Yuji,
Suehiro Yutaka,
Hamanaka Yuichiro,
Ueyama Yoshiya,
Yamashita Hiroshi,
Hinoda Yuji
Publication year - 2006
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.20140
Subject(s) - head and neck squamous cell carcinoma , biology , genotype , oncology , medicine , logistic regression , basal cell , epidermoid carcinoma , dna glycosylase , head and neck cancer , cancer research , genetics , carcinoma , dna repair , gene , cancer
Recent molecular epidemiological studies have demonstrated that the human oxoguanine glycosylase 1 ( OGG1 ) gene polymorphism may be associated with various cancers. To determine whether the OGG1 Ser326Cys polymorphism interacts with clinicopathological parameters including smoking and alcohol intake in head and neck squamous cell carcinoma (HNSCC), DNA samples from 192 patients with primary HNSCC were genotyped and studied by the case‐only design. We observed an association between the Cys/Cys genotype and HNSCC with cigarette smoking of more than 40 pack‐years by a multivariate logistic regression analysis (OR = 8.10, 95% CI = 1.06–61.73). No significant association of this genotype with alcohol intake was observed. Our present data suggest a possible interaction between the OGG1 Ser326Cys polymorphism and smoking in HNSCC. © 2005 Wiley‐Liss, Inc.