Characterization of medroxyprogesterone and DMBA‐induced multilineage mammary tumors by gene expression profiling | Zendy

Yin Yuzhi | Zendy; Bai Renkui | Zendy; Russell Robert G. | Zendy; Beildeck Marcy E. | Zendy; Xie Zhihui | Zendy; Kopelovich Levy | Zendy; Glazer Robert I. | Zendy

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Characterization of medroxyprogesterone and DMBA‐induced multilineage mammary tumors by gene expression profiling

Author(s) -

Yin Yuzhi,

Bai Renkui,

Russell Robert G.,

Beildeck Marcy E.,

Xie Zhihui,

Kopelovich Levy,

Glazer Robert I.

Publication year - 2005

Publication title -

molecular carcinogenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.254

H-Index - 97

eISSN - 1098-2744

pISSN - 0899-1987

DOI - 10.1002/mc.20119

Subject(s) - biology , dmba , carcinogenesis , cancer research , gene expression profiling , myoepithelial cell , immunohistochemistry , mammary gland , gene expression , gene , pathology , cancer , breast cancer , genetics , immunology , medicine

Mouse mammary tumors arising during medroxyprogesterone‐DMBA‐mediated mammary carcinogenesis comprised three distinct phenotypes: adenocarcinoma, squamous cell carcinoma, and myoepithelial carcinoma. The molecular signature for each of the three tumor subsets was characterized by gene microarray analysis, and three distinct sets of gene expression profiles were obtained that were corroborated in part by quantitative RT‐PCR and immunohistochemistry. These results suggest that this carcinogenesis and gene expression model will be useful for rapidly assessing the histopathological differences arising in mammary carcinogenesis and the effects of tumor promoting or chemoprevention agents. Published 2005 Wiley‐Liss, Inc.

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