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Tlag2 , an N ‐methyl‐ N ‐nitrosourea susceptibility locus, maps to mouse chromosome 4
Author(s) -
Angel Joe M.,
Richie Ellen R.
Publication year - 2002
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/mc.10026
Subject(s) - biology , locus (genetics) , genetics , allele , gene , chromosome , inbred strain , chromosome 4 , gene mapping , quantitative trait locus , microbiology and biotechnology
Abstract Susceptibility to N ‐methyl‐ N ‐nitrosourea (MNU)–induced lymphomas is a multigenic trait. We previously mapped a resistance locus ( Tlag1 ) to mouse chromosome 7 in genetic crosses of sensitive AKR with resistant C57L mice. Analysis of the MNU sensitivity of AKXL recombinant inbred strains that are homozygous for the AKR allele of Tlag1 suggested that at least two additional tumor susceptibility loci segregate in these crosses. A second susceptibility locus ( Tlag2 ) now has been mapped to chromosome 4. Only those mice that inherited the susceptibility alleles at both Tlag1 and Tlag2 were sensitive to MNU induction of thymic lymphomas, suggesting that these two loci interact. Chromosome 4 has been associated with susceptibility to hematopoietic tumor development in several mouse models, suggesting that one or more genes mapping to this chromosome are important in lymphomagenesis in general. © 2002 Wiley‐Liss, Inc.