Open AccessImpact of antibiotics on the human microbiome and consequences for host health
Author(s) -
Patangia Dhrati V.,
Anthony Ryan Cornelius,
Dempsey Eugene,
Paul Ross Reynolds,
Stanton Catherine
Publication year - 2022
Publication title -
microbiologyopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.881
H-Index - 36
ISSN - 2045-8827
DOI - 10.1002/mbo3.1260
Subject(s) - antibiotics , microbiome , antibiotic resistance , host (biology) , biology , gut flora , human health , microbiology and biotechnology , immunology , medicine , ecology , bioinformatics , environmental health
It is well established that the gut microbiota plays an important role in host health and is perturbed by several factors including antibiotics. Antibiotic‐induced changes in microbial composition can have a negative impact on host health including reduced microbial diversity, changes in functional attributes of the microbiota, formation, and selection of antibiotic‐resistant strains making hosts more susceptible to infection with pathogens such as Clostridioides difficile . Antibiotic resistance is a global crisis and the increased use of antibiotics over time warrants investigation into its effects on microbiota and health. In this review, we discuss the adverse effects of antibiotics on the gut microbiota and thus host health, and suggest alternative approaches to antibiotic use.