Open AccessSchiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris
Author(s) -
Hamad Asad,
Chen Yiyuan,
Khan Mohsin A.,
Jamshidi Shirin,
Saeed Naima,
Clifford Melanie,
Hind Charlotte,
Sutton J. Mark,
Rahman Khondaker Miraz
Publication year - 2021
Publication title -
microbiologyopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.881
H-Index - 36
ISSN - 2045-8827
DOI - 10.1002/mbo3.1218
Subject(s) - candida auris , fluconazole , candida glabrata , antifungal , antifungal drugs , multiple drug resistance , candida infections , antifungal drug , microbiology and biotechnology , biology , drug resistance , fungal pathogen , pathogen
Invasive Candida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in several Candida species that cause Candidemia, including C . glabrata and C. auris , with limited numbers of antifungal agents available to treat patients with invasive Candida infections. Therefore, there is an urgent need to discover new antifungal agents that work against multidrug‐resistant Candida species, particularly C . auris , which has been identified as an emerging global pathogen. In this article, we report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against all Candida species tested, with an MIC range of 4–32 µg/ml. Compound 2b showed activity against C . glabrata and a panel of fluconazole‐resistant C . auris strains, with MICs of 4–16 µg/ml. The drug‐like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed toward pre‐clinical evaluation.