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Biophysical characterization of the complexation of C 60 fullerene with doxorubicin in a prokaryotic model
Author(s) -
Prylutskyy Y.,
Borowik A.,
Gołuński G.,
Woziwodzka A.,
Piosik J.,
Kyzyma O.,
Pashkova I.,
Ritter U.,
Evstigneev M.
Publication year - 2016
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.201600463
Subject(s) - fullerene , doxorubicin , molecule , characterization (materials science) , chemistry , combinatorial chemistry , neutron scattering , dna , small molecule , chemical physics , nanotechnology , computational chemistry , materials science , neutron , organic chemistry , physics , nuclear physics , biochemistry , biology , genetics , chemotherapy
By means of small‐angle neutron scattering and ames mutagenicity test it was shown that C 60 fullerene may act as an interceptor of the antibiotic doxorubicin by formation of a hetero‐complex with this drug. This result has been predicted based on previously developed model of chemico‐biological interaction between DNA‐binding drugs and aromatic interceptor molecules.