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Nanocomposites specifically penetrate and inhibit tumor cells
Author(s) -
Goltsev A. N.,
Malyukin Y. V.,
Dubrava T. G.,
Babenko N. N.,
Gaevskaya Y. A.,
Chelombytko O. V.,
Bondarovich N. A.,
Ostankova L. V.,
Dimitrov A. Y.,
Klochkov V. K.,
Kavok N. S.
Publication year - 2016
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.201600457
Subject(s) - nanocomposite , tumor cells , materials science , chemistry , biophysics , nanotechnology , composite material , cancer research , biology
A most important task in oncology today is the search for structures capable of specific targeting and inactivating the cancer stem cells determining the tumor growth. We describe the investigation of the ability of the synthesized hybrid nanocomplexes containing rare earth‐based nanoparticles of GdYVO 4 : Eu 3+ orthovanadates, cholesterol and the hydrophobic luminescent dye DiI to visualize and inactivate the cancer stem cells of the Ehrlich carcinoma. The spectral analysis revealed an intracellular accumulation of nanoparticles in the Ehrlich carcinoma cells. This fact suggested the implementation of antitumor effect of the nanoparticles in vivo . The treatment of the Ehrlich carcinoma cells with spherical nanoparticles at a concentration of 1.30 g/L was found to reduce the intensity of tumor growth by 58.2 %. Ehrlich carcinoma cell processing with a three component hybrid complex resulted in a maximum decrease in the concentration of the most carcinogenic CD44 hi cells with a simultaneous increase in the number of CD117 + cells, which reduced the intensity of tumor growth by 76.6 %. When applying hybrid nanocomplexes, a reduced expression rate of the oct4, sox2 and nanog genes in Ehrlich carcinoma cells was observed which may be a mechanism for the antitumor action of orthovanadates.