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Charakterisierung der Antitumor‐Immun‐Antwort auf C 60 Fullerene
Author(s) -
Didenko G.,
Prylutska S.,
Kichmarenko Y.,
Potebnya G.,
Prylutskyy Y.,
Slobodyanik N.,
Ritter U.,
Scharff P.
Publication year - 2013
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.201300082
Subject(s) - cytotoxic t cell , cytotoxicity , fullerene , immune system , in vivo , in vitro , lewis lung carcinoma , chemistry , cancer research , immunology , biology , medicine , biochemistry , cancer , organic chemistry , metastasis , microbiology and biotechnology
In vitro experiments have shown that C 60 fullerenes exhibit cytotoxic effects against tumor cells and modulate the cytotoxic activity of immune cells. In vivo therapeutic experiments on the model of Lewis lung carcinoma showed that C 60 fullerenes exhibit an antimetastatic effect (reduction of metastases by 27%), which is realized by activating macrophages and stimulating the synthesis of humoral factors, which significantly increase the cytotoxicity of treated animals serum.