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Biokompatible und biodegradierbare Mizellen aus MOPEO‐b‐PCL Diblock‐Compolymeren als Nanocontainer für pharmazeutische Wirkstoffe
Author(s) -
Partsevskaya S.V.,
Zheltonozhskaya T.B.,
Permyakova N.M.,
Kolendo A.Y.
Publication year - 2011
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.201100743
Subject(s) - copolymer , micelle , amphiphile , ethylene oxide , polymer chemistry , aqueous solution , materials science , fourier transform infrared spectroscopy , chemical engineering , hydrogen bond , dynamic light scattering , biocompatible material , chemistry , polymer , organic chemistry , nanotechnology , nanoparticle , molecule , medicine , engineering , biomedical engineering
Amphiphilic MOPEO‐ b ‐PCL diblock copolymers with biocompatible and biodegradable blocks of methoxypoly(ethylene oxide) ( M v = 2·10 3 ) and poly(ε‐caprolactone) of a variable chain length were synthesized.Their structure, the micellization in dioxane/aqueous solutions and also the interaction of micelles with the model drug prednisolon (PS) were studied by 1 H NMR, DSC, UV/visible spectroscopy, static light scattering and FTIR. A binding of PS by micellar nanocontainers by means of hydrogen bonds and hydrophobic interactions, that enhances essentially the stability of micellar structures in a solution, was established.