Biokompatible und biodegradierbare Mizellen aus MOPEO‐b‐PCL Diblock‐Compolymeren als Nanocontainer für pharmazeutische Wirkstoffe | Zendy

Partsevskaya S.V. | Zendy; Zheltonozhskaya T.B. | Zendy; Permyakova N.M. | Zendy; Kolendo A.Y. | Zendy

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Biokompatible und biodegradierbare Mizellen aus MOPEO‐b‐PCL Diblock‐Compolymeren als Nanocontainer für pharmazeutische Wirkstoffe

Author(s) -

Partsevskaya S.V.,

Zheltonozhskaya T.B.,

Permyakova N.M.,

Kolendo A.Y.

Publication year - 2011

Publication title -

materialwissenschaft und werkstofftechnik

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 38

eISSN - 1521-4052

pISSN - 0933-5137

DOI - 10.1002/mawe.201100743

Subject(s) - copolymer , micelle , amphiphile , ethylene oxide , polymer chemistry , aqueous solution , materials science , fourier transform infrared spectroscopy , chemical engineering , hydrogen bond , dynamic light scattering , biocompatible material , chemistry , polymer , organic chemistry , nanotechnology , nanoparticle , molecule , medicine , engineering , biomedical engineering

Amphiphilic MOPEO‐ b ‐PCL diblock copolymers with biocompatible and biodegradable blocks of methoxypoly(ethylene oxide) ( M v = 2·10 3 ) and poly(ε‐caprolactone) of a variable chain length were synthesized.Their structure, the micellization in dioxane/aqueous solutions and also the interaction of micelles with the model drug prednisolon (PS) were studied by 1 H NMR, DSC, UV/visible spectroscopy, static light scattering and FTIR. A binding of PS by micellar nanocontainers by means of hydrogen bonds and hydrophobic interactions, that enhances essentially the stability of micellar structures in a solution, was established.

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