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Synthesis and characterization of DNA‐functionalized calcium phosphate nanoparticles
Author(s) -
Sokolova V.,
Prymak O.,
MeyerZaika W.,
Cölfen H.,
Rehage H.,
Shukla A.,
Epple M.
Publication year - 2006
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.200600017
Subject(s) - zeta potential , dynamic light scattering , nanoparticle , colloid , precipitation , chemical engineering , transmission electron microscopy , calcium , aqueous solution , chemistry , dispersion (optics) , magnesium , materials science , nanotechnology , organic chemistry , physics , optics , meteorology , engineering
Calcium phosphate nanoparticles were prepared by precipitation from aqueous solution. A stable colloid was formed by coating with DNA. The properties of the colloidal dispersion can be adjusted by variation of the inorganic nanoparticles. In particular, the partial substitution of calcium by magnesium or aluminum led to stable dispersions of nanoparticles. By a multi‐step precipitation process, it is also possible to include DNA into the particles in order to protect it from intracellular biochemical degradation. The dispersions were analyzed by dynamic light scattering, zeta potential measurements, analytical ultracentrifugation, and transmission electron microscopy.