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Statistical Mechanical Modeling of Protein Adsorption
Author(s) -
Van Tassel P. R.
Publication year - 2003
Publication title -
materialwissenschaft und werkstofftechnik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 38
eISSN - 1521-4052
pISSN - 0933-5137
DOI - 10.1002/mawe.200300703
Subject(s) - adsorption , particle (ecology) , chemical physics , statistical model , protein adsorption , spectroscopy , chemistry , materials science , statistical physics , statistical mechanics , biological system , physics , computer science , quantum mechanics , artificial intelligence , geology , oceanography , biology
We present rationale for and a derivation of a statistical mechanical model of protein adsorption. Proteins are modeled as rigid geometric objects adsorbing initially in a reversible manner and subsequently undergoing an irreversible change in shape to a permanently adsorbed state. Both adsorption and shape change occur subject to energetic interactions with previously adsorbed proteins. We evaluate the model quantitatively for proteins with disk‐shaped projections within the scaled particle theory and compare the predictions to experimental measurements taken via optical waveguide lightmode spectroscopy.