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Conformational Study of Short Peptoid Models for Future Applications as Potent Antimicrobial Compounds
Author(s) -
Nandel Fateh Singh,
Saini Avneet
Publication year - 2007
Publication title -
macromolecular theory and simulations
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.37
H-Index - 56
eISSN - 1521-3919
pISSN - 1022-1344
DOI - 10.1002/mats.200600080
Subject(s) - peptoid , chemistry , combinatorial chemistry , antimicrobial , membrane , cationic polymerization , antimicrobial peptides , zeta potential , bioavailability , peptide , nanotechnology , biochemistry , organic chemistry , materials science , bioinformatics , biology , nanoparticle
Development of peptides as clinically useful drugs is limited by their poor metabolic stability and low bioavailability. Recent progresses in chemical synthesis and design have led to several strategies for producing potent mimetics. This study aims to analyze sequence/structure requirements and composition for antimicrobial peptoid designs, as use of peptoids is one of the most representative approaches to meet the goal of biomimicry. Analysis of the designs showed that for maximum activity and minimum hemolysis, the plane of the aromatic residues should be at an angle between 0 and 90 ° with respect to membranes, cationic residues need not be at the terminal position, and central positions should be uniform in NIle, NLys, and NPhe residues.