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Biodegradable Microcapsules from D,L–PLA/PCL as Controlled Nifedipine Drug Delivery Carrier
Author(s) -
Astuti Suci Hepy,
Rahma Wanda Amelia,
Budianto Emil
Publication year - 2020
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201900132
Subject(s) - nifedipine , dissolution , dissolution testing , materials science , drug delivery , dichloromethane , drug carrier , chemical engineering , nuclear chemistry , chromatography , chemistry , nanotechnology , calcium , solvent , organic chemistry , metallurgy , biopharmaceutics classification system , engineering
In this study, microcapsules are prepared as a controlled drug Nifedipine delivery carrier. Nifedipine is a calcium channel blocker, it is widely used in the treatment of angina pectoris and hypertension. The microcapsules are prepared using o/w emulsification method. The core materials of microcapsules are polyblend of D,L‐poly(lactic acid) (PLA) and poly(ɛ‐caprolactone) (PCL) using Span 80 and Tween 80 as an emulsifier. D,L‐PLA, and PCL are dissolved into dichloromethane then emulsified and dispersed into water to form microcapsules. The sizes, uniformity of microcapsules, and the ability to encapsulate the drug are influenced by the composition of D,L‐PLA, and PCL. This study observes the appearance, ability to encapsulate the drug, and the dissolution at the various compositions ratio of D,L‐PLA:PCL. The blend of D,L‐PLA, and PCL is only formed through physical interaction between them. The surface texture of microcapsules is observed by optical microscope. It obtains that the composition of D,L‐PLA (80):PCL (20) shows the best ability to encapsulate the drug with evidently obtaining the highest encapsulation efficiency by 86.58%. The best microcapsule dissolution test results in drug release of 24.01% within 55 h.