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Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering
Author(s) -
Mizuta Ryo,
Devos Juliette M.,
Narayanan Theyencheri,
Oliva Mizar,
Gray Melissa,
Webster Jessica,
Ling WaiLi,
Round Adam,
Munnur Deeksha,
Mossou Estelle,
Farahat Abdelbasset,
Boykin David W.,
Wilson W. David,
Neidle Stephen,
Schweins Ralf,
Rannou Patrice,
Haertlein Michael,
Forsyth V. Trevor,
Mitchell Edward
Publication year - 2019
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201800243
Subject(s) - nanotube , dna origami , halide , nanotechnology , materials science , self assembly , alkali metal , transmission electron microscopy , chemical physics , ribbon , groove (engineering) , chemistry , carbon nanotube , nanostructure , inorganic chemistry , composite material , organic chemistry , metallurgy
A systematic study into a novel self‐assembling system is presented whereby the small molecule DB921 forms nearly monodisperse nanotubes upon addition of a suitable salt. Small‐angle X‐ray scattering and negative stain transmission electron microscopy are employed as the principal characterization methods to study both the fundamental assembly processes and reaction kinetics. The assembly is found to be hierarchical, culminating with helical winding of intermediate ribbon structures into nanotubes. The driving force for this process is likely the electrostatic interaction between DB921 and salt anions; this aspect can be used to control nanotube assembly and morphology.