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Study of Interaction between Human Hemoglobin and Antitubercular Isoniazid Drug with Its Detection
Author(s) -
Patil Shilpa R.,
Mahanwar Sunanda T.,
Gunjal Datta B.,
Wakshe Saubai B.,
Anbhule Prashant V.,
Kolekar Govind B.
Publication year - 2019
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201800203
Subject(s) - hemoglobin , isoniazid , fluorescence , chemistry , hydrazide , drug , chromatography , pharmacology , biochemistry , tuberculosis , organic chemistry , medicine , pathology , physics , quantum mechanics
The high intake of antitubercular isonicotinyl hydrazide (INH) is hazardous to human body. Hence, there is a need for its detection. For this reason, we study interaction between human hemoglobin (HHb) and INH by applying fluorescence and UV–vis spectroscopic techniques. Fluorimetric as well as UV–vis results showed the formation of complex between HHb and INH. The proposed HHb‐based fluorescence method was applied directly for the determination of INH in pharmaceutical sample.