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An Efficient Protocol for the Synthesis of Pyrido[2,3‐ d ]pyrimidines in Glycerol–Water Medium: Assessment by Green Chemistry Metrics
Author(s) -
Jamale Dattatraya K.,
Gurame Vashishtha M.,
Valekar Navanath J.,
Hangirgekar Shankar P.,
Kolekar Govind B.,
Anbhule Prashant V.
Publication year - 2019
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201800202
Subject(s) - glycerol , malononitrile , green chemistry , pyrimidine , catalysis , chemistry , aldehyde , condensation , organic chemistry , condensation reaction , protocol (science) , water chemistry , reaction conditions , combinatorial chemistry , reaction mechanism , biochemistry , environmental chemistry , physics , thermodynamics , medicine , alternative medicine , pathology
A clean and ecofriendly approach for the catalyst‐free synthesis of pyrido[2,3‐ d ]pyrimidine derivatives by one‐pot three‐component condensation of aromatic aldehyde, malononitrile and 6‐aminouracil or 6‐amino‐1,3‐dimethyluracil using glycerol–water (3:1) as green reaction media has been developed. Catalyst‐free synthesis with high to excellent yields and use of glycerol–water system as an environmentally benign reaction condition are the prominent features of this strategy. Moreover, excellent outcomes from the calculations of green chemistry metrics reveal the greenness of the protocol.