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Comparative Characterization of Melt Electrospun Fibers and Films Based on PLA‐PHB Blends: Diffusion, Drug Release, and Structural Features
Author(s) -
Liu Yong,
Cao Kuan,
Karpova Svetlana,
Olkhov Anatoliy,
Filatova Anna,
Zhulkina Anna,
Burkov Andrey,
Fomin Sergey V.,
Rosa Derval S.,
Iordanskii Alexey L.
Publication year - 2018
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201800130
Subject(s) - materials science , crystallinity , diffusion , characterization (materials science) , chemical engineering , composite material , nanotechnology , physics , engineering , thermodynamics
Comparative structural‐dynamic characterization of the biopolyester blends based on poly(3‐hydroxybutyrate) and poly‐L‐lactide (PLA) [PHB/PLA] is performed. The melt electrospun fibers and molded films with the same compositions (1/0, 1/9, 3/7) but obtained by two different fabrication ways are explored by combination of structural and dynamic methods. The structural‐dynamic features such as segmental mobility (by spin‐probe ESR technique), thermophysical transitions (by DSC), and surface morphology (by SEM) are applied to elucidate the distinctive diffusion features as the essential constituent of drug release. The ultrathin electrospun fibers and molded films loaded by dipyridamole (DPD), as a modeling drug, shows the different structural behavior including crystallinity and the diversity in diffusion coefficients and the drug release profiles. To emphasize the special transport phenomena in nano‐sized drug vehicles, the diffusivity modeling is performed and further the drug diffusion coefficients in the ultrathin fibers and the macroscopic films are compared.