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Formation, Stability and Cytotoxicity of Precursor Microemulsions to Prepare Core‐Shell Polymeric Nanoparticles for Pharmaceutical Applications
Author(s) -
PeraltaRodríguez René D.,
FloresVillaseñor Sergio E.,
RamirezContreras Jorge C.,
de Araujo Daniele Ribeiro,
Rodrigues Tiago
Publication year - 2017
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201600129
Subject(s) - microemulsion , polyethylene glycol , chemistry , polymer , nanoparticle , paclitaxel , nanocapsules , materials science , chemical engineering , nuclear chemistry , chromatography , organic chemistry , nanotechnology , pulmonary surfactant , biochemistry , engineering , medicine , surgery , chemotherapy
The preparation of biocompatible normal (oil‐in‐water, o/w) microemulsions (ME) with different oil phases (peppermint oil, trans‐anethole, vitamin E, jojoba oil) and stabilized with d‐α polyethylene glycol succinate (TPGS‐1000) and isobutanol ( iso ‐BuOH) is presented. Results of average particle diameter determination, Dp, indicated 6.35 ≤ Dp ≤ 10.24 nm. These ME showed excellent colloidal stability (−40 and +40 °C) and, without any drug loaded, decreased dramatically the viability of leukemia cells (K562), 60–90 %, in 24 hours. Besides, this behavior was potentiated when paclitaxel (PTX, an anticancer drug) was loaded in the transanethole microemulsion, where the cell viability decreased until 2 % at 0.5 μg/mL of PTX. These MEs are precursors to synthetize polymeric nanocapsules when coated with a thermo or pH – sensible polymer with potential for cancer treatment.