Formation, Stability and Cytotoxicity of Precursor Microemulsions to Prepare Core‐Shell Polymeric Nanoparticles for Pharmaceutical Applications | Zendy

PeraltaRodríguez René D. | Zendy; FloresVillaseñor Sergio E. | Zendy; RamirezContreras Jorge C. | Zendy; de Araujo Daniele Ribeiro | Zendy; Rodrigues Tiago | Zendy

Premium

Formation, Stability and Cytotoxicity of Precursor Microemulsions to Prepare Core‐Shell Polymeric Nanoparticles for Pharmaceutical Applications

Author(s) -

PeraltaRodríguez René D.,

FloresVillaseñor Sergio E.,

RamirezContreras Jorge C.,

de Araujo Daniele Ribeiro,

Rodrigues Tiago

Publication year - 2017

Publication title -

macromolecular symposia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.257

H-Index - 76

eISSN - 1521-3900

pISSN - 1022-1360

DOI - 10.1002/masy.201600129

Subject(s) - microemulsion , polyethylene glycol , chemistry , polymer , nanoparticle , paclitaxel , nanocapsules , materials science , chemical engineering , nuclear chemistry , chromatography , organic chemistry , nanotechnology , pulmonary surfactant , biochemistry , engineering , medicine , surgery , chemotherapy

The preparation of biocompatible normal (oil‐in‐water, o/w) microemulsions (ME) with different oil phases (peppermint oil, trans‐anethole, vitamin E, jojoba oil) and stabilized with d‐α polyethylene glycol succinate (TPGS‐1000) and isobutanol ( iso ‐BuOH) is presented. Results of average particle diameter determination, Dp, indicated 6.35 ≤ Dp ≤ 10.24 nm. These ME showed excellent colloidal stability (−40 and +40 °C) and, without any drug loaded, decreased dramatically the viability of leukemia cells (K562), 60–90 %, in 24 hours. Besides, this behavior was potentiated when paclitaxel (PTX, an anticancer drug) was loaded in the transanethole microemulsion, where the cell viability decreased until 2 % at 0.5 μg/mL of PTX. These MEs are precursors to synthetize polymeric nanocapsules when coated with a thermo or pH – sensible polymer with potential for cancer treatment.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research