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Preparation of Magneto‐Sensitive Polymer Nanocomposite Microparticles from Copolyesterurethanes via Electrospraying
Author(s) -
Zhang Quanchao,
Sauter Tilman,
Wang Li,
Fang Liang,
Kratz Karl,
Lendlein Andreas
Publication year - 2014
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201400140
Subject(s) - nanocomposite , materials science , thermogravimetric analysis , polymer , nanoparticle , particle size , magnetic nanoparticles , dispersion (optics) , chemical engineering , composite material , nanotechnology , engineering , physics , optics
Summary Small stimuli‐responsive magneto‐sensitive microparticles (<5 μm) have attracted broad interest for biomedical applications, since they can be delivered minimal‐invasively (e.g. via injection) and guided to a specific site or organ, while using their magnetic properties. In addition, such particles can be remotely heated, e.g., for hyperthermia therapy approaches. In this study, we prepared magneto‐sensitive polymer‐based nanocomposite microparticles by electrospraying of a 1,1,1,3,3,3 hexafluoro‐2‐propanol solution containing a mixture of a copolyetheresterurethane (PDC) and magnetic Fe 3 O 4 nanoparticles (MNPs). Thermal gravimetric analysis (TGA) revealed a weight content of 23 ± 0.5 wt‐% MNPs in the PDC magneto‐sensitive nanocomposite microparticles, which was identical with the initial starting composition. Scanning electron microscopy (SEM) results indicated a bimodal particle size distribution for the prepared magneto‐sensitive nanocomposite microparticles around 1.2 ± 0.3 μm and 400 ± 100 nm, respectively. Decreasing the size of the magneto‐sensitive nanocomposite microparticles resulted in an increase in their reduced modulus, which was obtained via nanoindentation testing. The PDC magneto‐sensitive nanocomposite microparticles could be successfully manipulated in dispersion medium suspension with a permanent magnet, demonstrating their magneto‐sensitivity. In addition, the inductive heating capability of the microparticulate nanocomposites could be demonstrated for a thin compression molded test specimen, which could be heated to 44 °C in an alternating magnetic field. The results indicated that such magneto‐sensitive nanocomposite microparticles can be potentially used as magneto‐responsive shape‐memory microparticles for on‐demand and remotely controlled drug delivery.