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Reactive ABA‐Type Triblock Phospholipid Copolymer by ATRP and Its Chemical Functionalizations
Author(s) -
Chantasirichot Surasak,
Inoue Yuuki,
Ishihara Kazuhiko
Publication year - 2015
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201400078
Subject(s) - copolymer , glycidyl methacrylate , polymer chemistry , methacrylate , materials science , moiety , surface modification , glycidol , polymer , polymerization , epoxide , amphiphile , chemistry , organic chemistry , catalysis
Summary Reactive ABA‐type triblock phospholipid copolymers composed of poly(glycidyl methacrylate) (PGMA) as A segments and poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC) as B segments (PGMA‐ block ‐PMPC‐ block ‐PGMA (PM b G)) were synthesized via controlled/living polymerization. The PMPC moiety was hydrophilic and water‐soluble while PGMA containing an epoxide ring worked as the reactive group for interaction with the nucleophiles. These reactions provided a facile route to modify the copolymer for desired functions. In this study, we synthesized phenylboronic acid‐containing (PM b B) and diethanolamine‐containing (PM b D) copolymers by functionalizing PM b G. PM b B and PM b D spontaneously formed stable hydrogels in aqueous media without any external stimuli. Owing to the excellent biocompatibility of the PMPC segments and easy functionalization of the PGMA segments, these reactive triblock phospholipid polymers can prove useful in various biomedical applications.