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Synthesis and Characterization of Poly(Methyl Methacrylate) PMMA and Evaluation of Cytotoxicity for Biomedical Application
Author(s) -
Feuser Paulo E.,
Gaspar Pamela C.,
RicciJúnior Eduardo,
Silva Maria C. S. da,
Nele Marcio,
Sayer Claudia,
H. H. de Araújo Pedro.
Publication year - 2014
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201300194
Subject(s) - miniemulsion , cytotoxicity , dispersity , methyl methacrylate , zeta potential , materials science , polymerization , pulmonary surfactant , poly(methyl methacrylate) , methacrylate , nanoparticle , lecithin , polymer chemistry , chemical engineering , chemistry , nanotechnology , chromatography , polymer , in vitro , composite material , biochemistry , engineering
Summary The objective this work was the synthesis, characterization and evaluation of cytotoxicity poly(methyl methacrylate), PMMA, nanoparticles (NPs) produced using miniemulsion polymerization technique adopting azobisisobutylonitrile (AIBN) as initiator and biocompatible and biodegradable surfactant, lecithin and co‐stabilizer, miglyol 812 The NPs showed high stability during one year and an average diameter of 89 nm with polydispersity index of 0.11 and a zeta potential −48 mV. The PMMA NPs were tested for cytotoxicity in acute monocytic leukemia cells (THP1) and in human lung adenocarcinoma cells (A549). The PMMA NPs did not show any adverse effect on cell viability indicating their potential to encapsulate antitumor agents.