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Fingerprint Multiplicity in MALDI‐TOF Mass Spectrometry of Copolymers
Author(s) -
Horský Jiří,
Walterová Zuzana
Publication year - 2014
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201300122
Subject(s) - copolymer , mass spectrometry , ethylene glycol , matrix assisted laser desorption/ionization , analytical chemistry (journal) , mass spectrum , chemistry , time of flight mass spectrometry , size exclusion chromatography , desorption , materials science , ionization , polymer chemistry , chromatography , polymer , ion , organic chemistry , adsorption , enzyme
Summary Due to the limited resolution of matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry, the assignment of binary‐copolymer composition to the peak molecular weight observed in the spectrum is not unique. Consequently, several clusters, called fingerprints, appear on calculated 2‐D distribution, but usually only one of them corresponds to the sample composition. The ambiguity in the assignment of the composition to peaks in mass spectra of binary copolymers was explained in the framework of number theory and several criteria for identification of the correct fingerprint were proposed. The results were applied in analysis of poly(propylene glycol)‐ b ‐poly(ethylene glycol)‐ block ‐poly(propylene glycol) triblock copolymer Reverse Pluronic 17R4.