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Development of Tissue Adhesives Based on Amphiphilic Isocyanate‐ T erminated Trimethylene Carbonate Block Copolymers
Author(s) -
Bochyńska Agnieszka I.,
Sharifi Shahriar,
van Tienen Tony G.,
Buma Pieter,
Grijpma Dirk W.
Publication year - 2013
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201300101
Subject(s) - trimethylene carbonate , isocyanate , copolymer , materials science , adhesive , trimethylolpropane , polyethylene glycol , amphiphile , adhesion , ultimate tensile strength , carbonate , composite material , polymer chemistry , peg ratio , polymer , chemical engineering , polyurethane , finance , layer (electronics) , economics , metallurgy , engineering
Summary In this study, novel 3‐armed star‐shaped isocyanate‐terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond®, which is currently one of the strongest clinically used tissue adhesives.