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Novel Hydrophobic Biodegradable Ester‐Polymers Obtained via Azlactone Chemistry
Author(s) -
Kobauri Sophia,
Zavaradshvili Nino,
Dgebuadze Marina,
Tugushi David,
Katsarava Ramaz
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201250514
Subject(s) - hydrolysis , polymer , polymer chemistry , hexane , terephthalic acid , chemistry , biodegradable polymer , polyester , organic chemistry
Biodegradable polymers having a potential for constructing resorbable therapeutical micro‐ and nano‐containers were synthesized by interaction of bis‐azlactones with bis‐(L‐leucine)‐1,6‐hexylene diester/1,6‐diamino hexane either separately or as comonomers. The thermograms (DSC) all of them showed a wide endothermal peak within 55–120 °C with a maximum ranged from 86 °C to 96 °C. The peak was assigned to the melting of hydrophobic domains formed by aromatic terephthalic acid fragments in the polymeric backbones. Preliminary in vitro study showed that the ester‐bonds containing polymers obtained are biodegradable – α‐chymotrypsin catalyzed ester bonds hydrolysis rates ranged within 0.02–0.34 µmole/min.