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Superparamagnetic Nanocomposites of Poly(vinyl alcohol‐ graft ‐acrylonitrile) as Carrier for Magnetically Assisted Release of Ciprofloxacin
Author(s) -
Gupta Rashmi,
Bajpai A.K.
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201250510
Subject(s) - nanocomposite , superparamagnetism , vinyl alcohol , acrylonitrile , materials science , chemical engineering , polymer , polymer chemistry , nanoparticle , nuclear chemistry , magnetization , composite material , chemistry , copolymer , nanotechnology , physics , quantum mechanics , magnetic field , engineering
In the present study also a superparamagnetic nanocomposite of Poly (vinyl‐ alcohol‐g‐acrylonitrile) has been designed by homogeneous impregnation of iron oxide nanoparticles into the graft polymer matrix. The so prepared nanocomposite was characterized by FT‐IR, TEM and XRD techniques and studied for water sorption behavior and magnetization properties. The superparamagnetic nanocomposite was loaded with an antibiotic drug, ciprofloxacin (CFx), and its release behavior was investigated under varying experimental conditions such as chemical composition of the matrix, pH of the release media, applied magnetic field and percent loading of the drug. The drug transport mechanism was also analyzed using Ficks power law. The drug loaded magnetic nanocomposite was also studied for antibacterial and in‐vitro blood compatible properties.