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Development of Polyelectrolyte Complex Microparticles for the Encapsulation of Isoniazid
Author(s) -
Devi Nirmala,
Kakati Dilip Kumar,
Maji Tarun Kumar
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201250308
Subject(s) - chitosan , polyelectrolyte , glutaraldehyde , polymer , chemical engineering , pulmonary surfactant , materials science , particle size , scanning electron microscope , self healing hydrogels , fourier transform infrared spectroscopy , polymer chemistry , chemistry , chromatography , composite material , engineering
Polyelectrolyte complex microparticles of different sizes were prepared by optimising the ratio of chitosan and sodium carboxy methyl cellulose (SCMC). The yield of the polyelectrolyte complex was dependent on the ratio of the two polymers and the pH of the medium. % yield and viscosity measurements were carried out to evaluate optimum pH and the ratio of the two polymers that produced the highest yield. Effect of various factors like amount of surfactant, concentration of polymer on the formation and size of the microparticles were investigated. The microparticles formed were pH‐responsive. These microparticles were used as carrier for isoniazid. The loading efficiency and release behaviour of loaded microparticles were found to be dependent on the amount of crosslinker used, concentration of drug and time of immersion. Maximum drug loading efficiency was observed at higher immersion time. The release rates of isoniazid at different pH were investigated and compared. The sizes of the microparticles were investigated by scanning electron microscopy. Microparticles were further characterised by FTIR and X‐ray diffraction study. The present work aims at producing microparticles as antitubercular drug carrier by using chitosan and SCMC as polymers, glutaraldehyde as crosslinker and sunflower oil as reaction medium.