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In Situ Incorporation of Doxorubicin in Copolymer Particles During Suspension Polymerization
Author(s) -
Oliveira Marco Antonio M.,
Melo Príamo A.,
Nele Márcio,
Pinto José Carlos
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100249
Subject(s) - copolymer , suspension (topology) , methyl methacrylate , suspension polymerization , polymer chemistry , materials science , polymer , doxorubicin , chemical engineering , polymerization , kinetics , composite material , medicine , physics , mathematics , surgery , chemotherapy , quantum mechanics , homotopy , pure mathematics , engineering
Summary: This work reports the kinetic behavior and the molecular properties of obtained copolymers during vinyl acetate and methyl methacrylate suspension copolymerizations in presence of doxorubicin. The obtained spherical particles are intended for use as chemoembolization agents. It is shown that the presence of doxorubicin in the reaction medium promotes significant changes in the copolymerization kinetics and final molecular weight averages of the polymer product.