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Preparation and Cytotoxicity of Poly(Methyl Methacrylate) Nanoparticles for Drug Encapsulation
Author(s) -
Mendes Anderson N.,
Hubber Isabela,
Siqueira Mônica,
Barbosa Gleyce Moreno,
de Lima Moreira Davyson,
Holandino Carla,
Pinto José Carlos,
Nele Marcio
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100248
Subject(s) - miniemulsion , methyl methacrylate , nanoparticle , materials science , polymer , methacrylate , monomer , poly(methyl methacrylate) , polymerization , polymer chemistry , chemical engineering , nanotechnology , composite material , engineering
Summary: This work aimed to produce poly(methyl methacrylate) nanoparticles for use in drug encapsulation. The polymer nanoparticles were produced using miniemulsion polymerization technique. Monomer miniemulsion showed moderate stability and polymer average particle size was about 90 nm. PMMA nanoparticles were tested for toxicity in human leukemic cell strain K562 and they did not show any adverse effect on cell viability. Therefore, poly(methyl methacrylate) nanoparticles are suitable to encapsulate antitumor agents.