Premium
Innovative Cross‐Linked Polyurethane Networks Based on Cyclodextrins and Polyethylene Glycols: Inclusion Capacity and Potential Use as Controlled Release Carrier for Nifedipine
Author(s) -
de Araújo Márcia Valéria Gaspar,
Vieira João Victor Francisco,
da Silva Thiago Alessandre,
Kubota Tatiana,
Barboza Fernanda Malaquias,
Farago Paulo Vitor,
Zawadzki Sônia Faria
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100160
Subject(s) - thermogravimetric analysis , polyurethane , fourier transform infrared spectroscopy , polyethylene glycol , cyclodextrin , peg ratio , polymer , polymer chemistry , polymerization , nuclear chemistry , chemistry , dissolution , crystallinity , materials science , chemical engineering , organic chemistry , finance , engineering , economics , crystallography
Summary: Polymers derived from cyclodextrins show several biomedical applications. In this paper, six cross‐linked polyurethane networks based on β ‐cyclodextrin ( β CD) or hydroxypropyl‐ β ‐cyclodextrin (HP β CD) and polyethylene glycols (PEG 400, PEG 1500 or PEG 4000) were synthesized by the usual two‐step polymerization method. The polymers were characterized by Fourier‐transformed infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and X‐ray diffraction (XRD). The inclusion capacity was evaluated by the discoloration method of a phenolphthalein solution. In order to explore their potential use as controlled drug delivery systems, dissolution profiles and release behavior of inclusion complexes between PUR/TDI/ β CD/PEG4000 or PUR/TDI/HP β CD/PEG1500 and nifedipine (NIF) were investigated. FTIR assignments confirmed the formation of urethane linkages. XRD patterns revealed that the crystallinity decreased mainly due to the crosslinking process. TGA showed three stages of mass loss attributed to water loss, cleavage of urethane bonds and volatilization of decomposition products. The inclusion capacity of cyclodextrins cross‐linked with polyurethane was suitably maintained. Dissolution profiles demonstrated that the inclusion complexes PUR/TDI/ β CD/PEG4000‐NIF and PUR/TDI/HP β CD/PEG1500‐NIF are feasible systems for controlling drug release, showing a biexponential release behavior.