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Micellization and Structure of MOPEO‐ b ‐PCL Copolymers and Their Application as Nanocontainers for Drugs
Author(s) -
Partsevskaya Sofia,
Zheltonozhskaya Tatyana,
Gomza Yuriy,
Klepko Valeriy
Publication year - 2012
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100069
Subject(s) - copolymer , micelle , ethylene oxide , polymer chemistry , fourier transform infrared spectroscopy , materials science , hydrogen bond , hydrophobic effect , aqueous solution , chemical engineering , dynamic light scattering , proton nmr , chemistry , polymer , organic chemistry , molecule , nanoparticle , nanotechnology , engineering , composite material
Diblock copolymers (DBCs) of MOPEO‐ b ‐PCL containing biocompatible and biodegradable components: hydrophilic methoxypoly‐(ethylene oxide) ( M n = 2.5 kDa = const) and hydrophobic poly(ε‐caprolactone) of a variable chain length ( M n = 2.8 ÷ 24.3 kDa) were synthesized by an anionic ring‐opening block copolymerization. Their chemical and microphase structure were characterized using FTIR, NMR, DSC and WAXS. Self‐assembly of pure DBCs and those at the presence of a model drug prednisolon (PS) in dioxane/aqueous solutions was studied using visible spectroscopy and static light scattering. Increasing in the micellar stability at the PCL block lengthening and PS addition was revealed. The drug binding by DBC micelles due to hydrogen bonds and hydrophobic interactions was confirmed by FTIR.