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A Blend of Poly(ε‐caprolactone) and Poly[(ε‐caprolactone)‐ co ‐glycolide] with Remarkable Mechanical Features and Wide Applicability as Biomaterial
Author(s) -
Wischke Christian,
Löbler Marian,
Neffe Axel T.,
Hanh Bui Duc,
Zierke Michael,
Sternberg Katrin,
Schmitz KlausPeter,
Guthoff Rudolf,
Lendlein Andreas
Publication year - 2011
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100050
Subject(s) - caprolactone , biomaterial , materials science , degradation (telecommunications) , polycaprolactone , hydrolytic degradation , extrusion , hydrolysis , elongation , biocompatibility , chemical engineering , polymer chemistry , composite material , polymerization , polymer , chemistry , ultimate tensile strength , nanotechnology , organic chemistry , telecommunications , computer science , engineering , metallurgy
Hydrolytic degradation of poly(ε‐caprolactone) [PCL] can be enhanced by introduction of 8 wt.% glycolide leading to poly[(ε‐caprolactone)‐ co ‐glycolide] (PCG), which has a low elongation at break ε B of 4%. PCG/PCL blends (50/50 w/w) combined the advantageous features of its individual components such as mechanical properties similar to pure PCL (ε B, Blend : 900 ± 230%; ε B, PCL : 730 ± 50 at 20 °C), water uptake rates during degradation similar to pure PCG, and linear mass loss during bulk degradation independent from sample dimensions. The outcome of cytotoxicity studies was depending on the cell type with promising results, e.g., for Tenon fibroblasts. Easy processing of the blend was demonstrated by melt compression, foaming with CO 2 , and hot melt extrusion, suggesting a wide applicability as biomaterial, e.g., as drug carrier.