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In Vitro and In Vivo Evaluation of a Multifunctional Hyaluronic acid Based Hydrogel System for Local Application on the Retina
Author(s) -
Neffe A. T.,
Kobuch K. A.,
Maier M.,
Feucht N.,
Lohmann C. P.,
Wolfstein A.,
Streufert D.,
Kamlage S.,
Lendlein A.
Publication year - 2011
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100049
Subject(s) - hyaluronic acid , self healing hydrogels , biocompatibility , in vivo , retinal , triamcinolone acetonide , retina , retinal detachment , biophysics , in vitro , chemistry , biomedical engineering , drug delivery , materials science , ophthalmology , nanotechnology , biochemistry , anatomy , biology , polymer chemistry , medicine , organic chemistry , microbiology and biotechnology , neuroscience
Conventional treatment of retinal detachment with laser and/or triamcinolon acetonide (TAAC) does not prevent loss of vision in all patients. Therefore, the development of degradable hydrogel patches covering retinal breaks was envisioned as alternative. Stable hydrogels could be formed by crosslinking hyaluronic acid with 1,2,3,4‐diepoxybutane. Triamcinolone was diffusible in the gels. The hydrogels were slowly degrading, and mass loss during hydrolytic degradation was observed starting after three weeks. The sterilized gels showed excellent intraocular biocompatibility in vivo in rabbit eyes when applied as a patch on the retina. The good retinal adherence of the patch and absence of cellular growth and proliferation in and around the gel indicated the suitability as a material for a retinal patch to prevent cell‐migration and proliferation after a retinal break and for local drug application.